ABC Transporters Have Four Core Domains
نویسنده
چکیده
domains, the nucleotide binding domains (NBDs), but which have evolved to couple the energy released by binding and hydrolysis of ATP to processes other than transbilayer transport. These include proteins involved in chromatin organization (13), DNA repair, telomere maintenance (15, 44), and mRNA trafficking through the nuclear pore (23). The molecular mechanism described below for ATP catalysis by the NBDs and its coupling to transport is also likely to describe the conformational changes involved in these processes.
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